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Must be administered by slow IV injection and Per mezzo di fractional doses to allow for adequate time for pentobarbital to distribute into CNS. A time interval of ≥1 minute is required to determine the full effect of an IV quota.

Slow IV injection is essential, and patients should be carefully observed during administration. This requires that blood pressure, respiration, and cardiac function be maintained, vital signs be recorded, and equipment for resuscitation and artificial ventilation be available. The rate of IV injection should not exceed 50 mg/min for pentobarbital sodium.

Premature infants are particularly susceptible to the depressant effects of barbiturates. If barbiturates are used during labor and delivery, resuscitation equipment should be available.

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This effect is fully reversible unless hypoxic damage occurs. Consideration should here be given to the possibility of barbiturate intoxication even in situations that appear to involve trauma.

Barbiturates are respiratory depressants. The degree of respiratory depression is dependent upon misura. With hypnotic doses, respiratory depression produced by barbiturates is similar to that which occurs during physiologic sleep with slight click here decrease Per mezzo di blood pressure and heart rate.

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Barbiturates more info have caused postpartum hemorrhage and hemorrhagic disease Per mezzo di neonates; readily reversible with vitamin K therapy.

Pentobarbital primarily acts on the central nervous system (CNS). At elevated doses, pentobarbital functions as an anticonvulsant for emergent seizure control and for inducing medically induced comas. Studies have demonstrated the superiority of pentobarbital due to its faster brain penetration and shorter half-life, thereby making it the preferred treatment for refractory status epilepticus.

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There is no antidote for pentobarbital and overdose treatment is symptomatic and supportive. Treatment may require intubation and respiratory support, maintenance of blood pressure with medication and fluids, and maintenance of body temperature.